Clinical data | |
---|---|
Pregnancy cat. | ? |
Legal status | Investigational |
Pharmacokinetic data | |
Half-life | 7 hrs (simulated)[1] |
Identifiers | |
ATC code | None |
Chemical data | |
Formula | ? |
BI 224436 is an investigational new drug under development for the treatment of HIV infection. BI 224436 is the first non-catalytic site integrase inhibitor (NCINI). It inhibits HIV replication via binding to a conserved allosteric pocket of the HIV integrase enzyme. This makes the drug distinct in mechanism of action compared to raltegravir and elvitegravir, which bind at the catalytic site.[2] In October 2011, Gilead Sciences purchased exclusive rights to develop BI 224436 and several related compounds under investigation in Boehringer Ingelheim’s noncatalytic site integrase inhibitor program.[3][4]